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Among antioxidant enzymes, our recent studies have shown evidence of impaired functioning of the enzyme paraoxonase 1 (PON1) associated to high-density lipoprotein (HDL) in individuals with AD, with reduced protein levels and enzyme activity (60, 61)

Wang J, Feng X, Li Z, Liu Y, Yang W, Zhang T, et al

Briefly, a grown culture of Muller Hinton broth with pure bacterial colonies (1.0 10 6 CFU/mL) was inoculated with ascorbic acid at MIC and double MIC

Unlike many experimental NRF2 activators (e.g., synthetic electrophiles or natural compounds like sulforaphane), DMF has undergone extensive Phase III trials, demonstrating its efficacy and safety in humans